Vol. 41, No. 3-4, 1997 previous next

THE RELATIONSHIP BETWEEN BIOGHEMICAL PARAMETERS IN BLOOD AND THE DAMAGE TO CEREBRAL ULTRASTRUCTURE FOLLOWING ISCHAEMIA IN THE DOG

Pomfy, M., Guzy, J., Franko, J., Nováková, B., Bélová, V., Gaško, G.*

Faculty of Medicine
P. J. Šafárik University
Šrobárova 2
040 01 Košice
Slovak Republic		 * Air Force Military Hospital
Murgašova 9
040 01 Košice
Slovak Republic

Summary

The aim of the present study was to determine the relationship between the ultrastructural response of cerebral nervous tissue and the total reaction of an organism to complete cerebral ischaemia and the subsequent reperfusion damage. Our biochemical and histopathological results indicate that high values of serum lactate point to irreversible damage to nervous tissue and marked disturbance of the internal environment. Even the cerebral reperfusion carried out for 24 h failed to bring the level of serum lactate and the acid-base balance back to the reference values despite good systemic circulation and respiration. All the experimental animals were in a coma during the reperfusion. The irreversible damage to morphological brain structures resulting from complete cerebral ischaemia was accompanied with serious impairment of the internal environment.

Key words: cerebral ischaemia; lactate acidosis; tissue ultrastructure; reperfusion damage; electron microscopy

References

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Folia Veterinaria / 1997