Vol. 41, No. 3-4, 1997
AN ELECTRON MICROSCOPIC STUDY OF THE HEPATOCYTES OF RATS OF DIFFERENT AGE AFTER GAMMA IRRADIATION
Daxnerová, Z., Kropáčová, K., Eliášová, V, Horák, J.
Faculty of Science
P. J. Šafárik University
Moyzesova 11
041 67 Košice
Slovak Republic
Summary
In this work we present the results of an ultrastructural study of changes in the liver cells of rats of different stages after continuous gamma irradiation. Male Wistar rats aged 1, 3 and 9 months were used. Each group was continuously irradiated by gamma rays (60Co) at a daily dose of 0.6 Gy for 21 days. After the termination of irradiation samples of liver were removed and prepared for transmission electron microscopy. The irradiation caused some alterations in the ultrastructure of liver cells. Amongst the most frequently observed changes, the dilatation of endoplasmic reticulum, and in an some cells, also an enlargement in size of lipid drops were observed. The changes in the nuclear ultrastructure were not very extensive. In some nuclei more perinuclear and perinucleolar condense heterochromatin appeared. The described alterations varied in rats of different ages. The most significant changes were found in 3 month old animals. The character of changes at the ultrastructural level enables us to predict the reparation of these damages.
Key words: liver cells; rat; electron microscopy; gamma rays
References
Folia Veterinaria / 1997