Vol. 43, No. 1, 1999 previous next

PATHOMORPHOLOGICAL INVESTIGATIONS INTO EXPERIMENTAL LEAD POISONING IN SHEEP

Stoev, S.*, Lazarova, S.**

*Department of Pathomorphology
Faculty of Veterinary Medicine
Thracian University, Student campus
6000 Stara Zagora
Bulgaria		 **Institute of Experimental Pathology and Parasitology
Bulgarian Academy of Sciences
Sofia
Bulgaria

Summary

An investigation was conducted in dynamics of the development of pathomorphological changes in the internal organs of 10 sheep, treated experimentally with sublethal doses of lead. Early histological damage to the kidneys was established using intravital biopsies in some of the experimental animals. Gross pathology examination revealed an ulceration and greyish colour in the gingiva; dark greyish-red colour, necroses, and erosion on the mucosa of the abomasum and intestine; yellowish-clay colour of the liver; dark-reddish medulla and pale-reddish cortex of the kidneys; haemorrhages on the serous membrane of the intestine, kidneys, and liver; hyperaemia in the brain envelope. Histological examination revealed pronounced dystrophic changes in the epithelium of convoluted tubules in the renal cortex, endothelial proliferation in the glomeruli; granular or lipid dystrophy and small necroses in the liver; dystrophic changes and small necroses in the superficial epithelium of the intestinal mucosa, and mononuclear cell infiltration in the lamina propria of the mucosa of the small intestine; pronounced dystrophic changes and pericellular or pericapillary oedema in the brain, hypothalamus as well as in the region of Purkinje's cells of the cerebellum; dystrophy and haemorrhages in the myocardium.

Key words: lead intoxication; sheep; pathomorphology

References

Back Logo UVM Forward

Folia Veterinaria / 1999