Vol. 44, No. 1, 2000 previous next

CHANGES IN ACTIVITIES OF ADAPTIVE ENZYMES IN LABORATORY RATS DURING CONTINUOUS GAMMA IRRADIATION

Toropila, M., Ahlers, I.*, Ahlersová, E.*, Ondrašovič, M., Beňová, K., Danko, J., Švický, E., Vargová, M.

University of Veterinary Medicine
Komenského 73
041 81 Košice
The Slovak Republic		 * Šafárik University, Faculty of Science
Moyzesova 11
041 76 Košice
The Slovak Republic

Summary

Changes in liver activities of selected adaptive enzymes were investigated in male rats of Wistar strain SPF breeding subjected to long-term continuous gamma irradiation with a daily dose of 0.6 Gy. The activity of tyrosine aminotransferase and tryptophan-2-3-dioxygenase in the liver of irradiated animals increased in two phases and correlated with changes in serum corticosterone. The activity of aspartate aminotransferase in the liver of irradiated animals decreased with the exception of day 14 lasting 90 days. The decrease was significant starting from day 21 up to the end of the investigated period. The activity of alanine aminotransferase in rat liver was increased significantly on days 14, 21 and 60 of irradiation and decreased on days 7 and 90 of irradiation. During the irradiation, the animals consumed less feed and their body weight decreased too.

Key words: gamma radiation; rat; liver; serum; tyrosine aminotransferase; tryptophan-2-3-dioxygenase; alanine aminotransferase; aspartate aminotransferase; corticosterone

References

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Folia Veterinaria / 2000