Vol. 44, No. 2, 2000
THE ACTION OF NADPH-DIAPHORASE ON THE STRUCTURES OF THE SCIATIC NERVE IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES
Lovásová, K., Kluchová, D., Schmidtová, K., Miklošová, M., Rybárová, S.
Faculty of Medicine
P. J. Šafárik University
Šrobárova 2
040 01 Košice
The Slovak Republic
Summary
This article concerns observations in the early stages of streptozotocin-induced diabetes on the sciatic nerve of Wistar rats. The expressive dilation of microvessels with various diameters, which run in the endoneurium and perineurium, is probably caused by endothelial dysfunction, reduced nerve perfusion, and by the excessive amount of NO molecules released. The occurrence of pathologically altered vessels in the diabetogenously damaged sciatic nerve were so determined. Numerous, short and thin capillaries (slightly wavy), especially in the endoneurium were also observed.
The occurrence of fine nitrergic nerve fibres along the capillaries which run in the endoneurium and perineurium of this peripheral nerve was confirmed.
Key words: diabetes mellitus; NADPH-diaphorase; NO; sciatic nerve; vessels; rat; streptozotocin
References
Folia Veterinaria / 2000