Vol. 45, No. 1, 2001 content next

THE EFFECT OF TILMICOSIN ON ANTIPYRINE PHARMACOKINETICS IN CHICKENS

Bakırel, T., Keleş, O., Dağoğlu, G. *, Baydan, E. **

Department of Pharmacology and Toxicology
Faculty of Veterinary Medicine
Istanbul University
Avcılar, Istanbul
TURKEY		 * Department of Pharmacology and Toxicology
Faculty of Veterinary Medicine Yüzüncü Yıl University
Van
TURKEY		 ** Department of Pharmacology and Toxicology
Faculty of Veterinary Medicine
Ankara University
Dışkapı, Ankara
TURKEY

Summary

Tilmicosin is a novel semi-synthetic macrolide antibiotic, developed specifically for veterinary use. To investigate the effect of tilmicosin treatment on the pharmacokinetics of antipyrine we used a model compound for determine the changes in the activities of oxidative drug-metabolizing enzymes in chickens. Two groups of 24 healthy chickens weighing 1.5 kg, received antipyrine i. v. at 20 mg/kg, after which blood samples were taken at 0.25, 0.5, 1, 2, 4, 6, and 8 hours. Tilmicosin was given to one group at 50 mg/kg orally 6 days after the first antipyrine dose. Antipyrine was given i. v. again, 24 hours after tilmicosin treatment and blood samples taken as before. The antipyrine test was also repeated with the controls. The values of antipyrine pharmacokinetic parameters were calculated on the basis of changes in the concentration of antipyrine in plasma. The disposition of antipyrine was best described by an open two-compartment model. Tilmicosin caused an increase in the elimination half-life of antipyrine as well as an increase in the area under the plasma concentration-time curve and alpha value. Antipyrine mean residence time was longer. None of the differences observed was significant except for the alpha value. We concluded that tilmicosin treatment had no significant effect on the pharmacokinetics of antipyrine.

Key words: tilmicosin; antipyrine; pharmocokinetic; chicken

References

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Folia Veterinaria / 2001