Vol. 45, No. 2, 2001
CELLULAR IMMUNITY IN PERSISTENT CUTANEOUS PAPILLOMATOSIS OF CATTLE
Paulík, Š., Mojžišová, J., Levkutová, M., Švrček, Š., Lešník, F., Ledecký, V.
University of Veterinary Medicine
Komenského 73
041 81 Košice
The Slovak Republic
Summary
The CD3+ and IgM+ cell proportions and the functional activity of blood lymphocytes and neutrophils were evaluated in bulls with persistent cutaneous papillomatosis. During clinical manifestation of papillomatosis (persistent for more than 1 year), the blastogenic response of lymphocytes to T-cell mitogens had significantly decreased in regard to the intensity of stimulated, non-stimulated cells, and the stimulation index. In the regression period of skin papillomas (induced by surgical excision of larger papillomas and by application of autologous tissue vaccine) a gradual elevation of the lymphocytic activity was found. At the end of our observation (day 139 after surgery), this was comparable with the lymphocytic activity in control animals.
The CD3+ and IgM+ cell proportions in blood and the phagocytic activity of neutrophils in the affected bulls were not significantly altered on any day of the observation. Similar results were demonstrated in total leukocyte, lymphocyte, and neutrophil counts. The average values were within the reference values.
Key words: cattle; papillomatosis; blastogenesis of lymphocytes; phagocytic activity of neutrophils; CD3+ and IgM+ cell proportions
References
Folia Veterinaria / 2001