Vol. 45, No. 2, 2001 content next

THE EFFECT OF DANOFLOXACIN ON PHARMACOKINETIC PROPERTIES OF ANTIPYRINE* DEPENDING ON THE STAGE OF THERAPY

Keleş, O., Bakirel, T., Sener, S., Baydan, E., Dağoğlu, G.

Department of Pharmacology and Toxicology
Faculty of Veterinary Medicine
Istanbul University
Avcılar
34851, Istanbul
TURKEY		 * Department of Pharmacology and Toxicology
Faculty of Veterinary Medicine
Ankara University
65080, Ankara
TURKEY		 ** Department of Pharmacology and Toxicology
Faculty of Veterinary Medicine
Yüzüncü-Yıl University
3640, Van
TURKEY

Summary

A fluoroquinolone, danofloxacin, was evaluated for its ability to alter hepatic microsomal drug-metabolism function. The influence of treatment with danofloxacin at a dose rate of 5 mg.kg body weight-1 once a day orally for 3 and 6 consecutive days on the pharmacokinetics of antipyrine (20 mg/kg) was investigated in chickens. After danofloxacin treatment for 3 consecutive days, the area under the curve, mean residence time, and the elimination half-life of antipyrine were significantly higher than in the chickens before danofloxacin treatment and in the control group, whereas alpha decreased significantly. The administration of danofloxacin at the same dose for 6 days increased the area under the curve and mean residence time of antipyrine without any changes in half-life as compared with danofloxacin treatment for 3 days. The results suggest that the danofloxacin is capable of inhibiting oxidative metabolism.

Key words: danofloxacin; pharmacokinetic; antipyrine

References

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Folia Veterinaria / 2001