Vol. 45, No. 4, 2001 content next

THE ANTIMICROSPORIDIAL EFFECT OF ALBENDAZOLE IN RABBITS EXPERIMENTALLY INFECTED BY Encephalitozoon cuniculi

Neuschl, J., Bálent, P., Štefkovič, M., Levkutová, M., Hipíková, V., Halánová, M*., Šály, J., Valenčáková, A.

University of Veterinary Medicine
Komenského 73
041 81 Košice
The Slovak Republic		 *Faculty of Medicine
P. J. Šafárik University
Šrobárova 2
041 80 Košice
The Slovak Republic

Summary

The development of experimentally induced encephalitozoonosis (Encephalitozoon cuniculi) was observed in 12 adult female rabbits of the New Zealand white breed. Animals from the negative control group were not infected by microsporidia. Animals from the positive control group were infected by Encephalitozoon cuniculi microsporidia with a single intraperitoneal dose of 5.107 ml-1. Animals from the experimental group after inoculation with Encephalitozoon cuniculi in the same dose and way were subsequently administered albendazole - in the form of Aldifal 2.5% susp. a.u.v. (MEVAK - SR) in a dose 5 mg.kg-1 of body weight (in a volume of 0.2 ml per os by a tube) from day 7 p.i., twice a week for 11 weeks and overall this was applied 21 times.
During the experiment the increase in body weight and the development of the clinical symptomatology of the disease were observed in relation to the serological prevalence.

Key words: Encephalitozoon cuniculi; rabbits; encephalitozoonosis; therapy; albendazole

References

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Folia Veterinaria / 2001